Pure® Encapsulations SAMe provides S-adenosylmethionine. S-adenosylmethionine (SAMe) is a natural compound that is present in all cells and is involved in the synthesis, activation and metabolism of different molecules. SAMe is a precursor to glutathione, an endogenous molecule that intervenes in the phases of liver detoxification. Indications: For those seeking to support toxin elimination processes. How to use: 1 capsule a day between meals. Acid resistant capsules, do not open them when consuming. Caution: If you are pregnant, nursing, have any health conditions, or take any medications, consult your healthcare professional before using this supplement. Conservation: Store in a cool, dry place.